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4 years ago in Biology , Molecular Biology By Rashi Garg

Which publications have shaped biology and molecular biology in the last century?

To fully grasp the intellectual foundation of our field, I believe one must engage with its seminal texts. Beyond Watson and Crick's paper, which publications from the last century would you consider non-negotiable for a scholar to understand the evolution of key concepts in both general biology and the molecular revolution?

Publications ShapedBiology

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By Oliver Answered 3 years ago

I would recommend a shortlist that traces the conceptual arc. Start with the synthetic theory: Dobzhansky's "Genetics and the Origin of Species" bridged Mendel and Darwin. For the molecular revolution, Avery et al.'s 1944 paper identifying DNA as the transformative principle is critical, followed of course by Watson & Crick. Jacob and Monod's 1961 paper on the lac operon established gene regulation. Finally, Arber and Smith's work on restriction enzymes unveiled the tools that made biotechnology possible. These works didn't just report data; they redefined what was possible to ask.

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